Catalytic Asymmetric Synthesis of Highly Substituted Pyrrolizidines.

نویسندگان

  • Andrew D Lim
  • Julian A Codelli
  • Sarah E Reisman
چکیده

A catalytic asymmetric double (1,3)-dipolar cycloaddition reaction has been developed. Using a chiral silver catalyst, enantioenriched pyrrolizidines can be prepared in one flask from inexpensive, commercially available starting materials. The pyrrolizidine products contain a variety of substitution patterns and as many as six stereogenic centers.

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عنوان ژورنال:
  • Chemical science

دوره 4 2  شماره 

صفحات  -

تاریخ انتشار 2012